View all jobs
Senior Biostatistician and Junior Biostatistician – Washington, DC
Washington, Dc · Government/MilitarySenior Biostatistician and Junior Biostatistician – Washington, DC
*Opportunity Is Contingent and Based on Bid and Award*
Background:
The National Institutes of Health (NIH) is the foremost federally funded biomedical research institution in the United States. It is comprised of twenty-seven Institutes, Centers and Divisions. The NIH Clinical Center is the on-site 200-bed hospital for the NIH campus comprised of clinical, laboratory and administrative staff who support the Institutes as they conduct clinical research working with inpatients and outpatients participating in research studies at the NIH.
The Critical Care Medicine Department (CCMD) was established in November 1977 to provide medical care for critically ill patients throughout the Clinical Center who have potentially reversible medical problems. The mission of the Department is to (a) provide superb care for Clinical Center patients who may benefit from critical care services, (b) improve both understanding and management of the critical disease processes, c) train health care professionals to understand, provide, and improve critical care services.
The Clinical Epidemiology Section (CES) of CCMD oversees clinical research leveraging large administrative and clinical databases to address pressing clinical concerns in the domains of severe infections and the critically ill. An important research focus of the CES is to characterize serious infections, sepsis and antimicrobial resistance in the United States, and its associated outcomes. The CES collaborates with federal partners (the Centers for Diseases Control and Prevention and the Food and Drug Administration) as well as several academic partners (Harvard Medical School, University of Maryland, Emory University) partners in these population-level studies.
Purpose:
The Clinical Epidemiology Section is continuously expanding the scope of its research, with an increasing number of independently funded projects. There are several ongoing and planned projects that require advanced statistical support and special application of machine learning and artificial intelligence to real world data, a unique requirement not currently available among the personnel in NIH Clinical Center Biostatistics core.
The major focus will be on the conduction of target trial emulations for identifying treatments for serious infections carrying a high burden of mortality. Signals from such studies could yield critical evidence which could prove life saving for many.
In the planned projects, CES investigators will conduct a retrospective cohort study using clinical and administrative data from the Premier Healthcare Database ©. It is anticipated that this project will involve a primary analysis of data from approximately 500,000 – 1, 000,000 patients. This will be coupled with weighted extrapolations and geospatial analyses using multiple national-level datasets accessible to the investigators to derive a national or quasi-national burdens as well as retrospective chart review from collaborating health centers across the United States to validate some assumptions in the initial cohort study.
Given the expansive nature of the study, there is a need for additional qualified personnel with expertise in statistical analysis to assist in the completion of this work.
Scope of Work:
A Biostatistician team of 2 individuals (senior PHD biostatistician with several years’ experience in academic and cutting edge biostatistical work and one junior Master-level biostatistician) will interface with other members of the Clinical Epidemiology Section, and informatics company (contracted for data curation), to conduct the analysis of data pertaining to several ongoing research studies. The major focus will be on the conduction of target trial emulations for identifying treatments for serious infections carrying a high burden of mortality.
The Biostatisticians will meet with the study investigators on a weekly basis to discuss and plan the data curation steps as well as the cohort design. The actual curation of the data will be performed by the contracted informatics company, but the biostatistician team will be involved from the inception phase in real-time discussions with the data curators to ensure the study dataset is constructed in a manner to enable planned analyses.
The Biostatisticians will receive the curated dataset consisting of clinical and administrative information for patients admitted to hospitals reporting to PHD. They will be responsible for the selection of the matching, weighting and modeling strategies employed to minimize bias including the handling of missing data. They will be responsible the generation of a statistical analysis plan for the proposal (which will be posted online prior to analysis), providing descriptive and summary statistics for the cohorts and identified subgroups, providing periodic presentations of preliminary data and 6-monthly interim analysis reports, as well as for the inferential analysis comparing the outcomes and costs of patients. Preliminary flow diagrams of the retrospective cohorts isolated from the PHD for this study are attached.
Qualifications:
The Senior Biostatisticians must meet the following requirements:
Requirements and Period of Performance:
This requirement will include a base year of twelve (12) months, with up to one (1) option period to extend the services solely by the discretion of the government.
Base Year: April 1, 2025, to March 31, 2026
Location:
Work is remote and research will be performed at the George Washington University, Washington, DC 20052
Point of Contact for Immediate Consideration:
Art Mata
amata@reef-syss.com
*Opportunity Is Contingent and Based on Bid and Award*
Background:
The National Institutes of Health (NIH) is the foremost federally funded biomedical research institution in the United States. It is comprised of twenty-seven Institutes, Centers and Divisions. The NIH Clinical Center is the on-site 200-bed hospital for the NIH campus comprised of clinical, laboratory and administrative staff who support the Institutes as they conduct clinical research working with inpatients and outpatients participating in research studies at the NIH.
The Critical Care Medicine Department (CCMD) was established in November 1977 to provide medical care for critically ill patients throughout the Clinical Center who have potentially reversible medical problems. The mission of the Department is to (a) provide superb care for Clinical Center patients who may benefit from critical care services, (b) improve both understanding and management of the critical disease processes, c) train health care professionals to understand, provide, and improve critical care services.
The Clinical Epidemiology Section (CES) of CCMD oversees clinical research leveraging large administrative and clinical databases to address pressing clinical concerns in the domains of severe infections and the critically ill. An important research focus of the CES is to characterize serious infections, sepsis and antimicrobial resistance in the United States, and its associated outcomes. The CES collaborates with federal partners (the Centers for Diseases Control and Prevention and the Food and Drug Administration) as well as several academic partners (Harvard Medical School, University of Maryland, Emory University) partners in these population-level studies.
Purpose:
The Clinical Epidemiology Section is continuously expanding the scope of its research, with an increasing number of independently funded projects. There are several ongoing and planned projects that require advanced statistical support and special application of machine learning and artificial intelligence to real world data, a unique requirement not currently available among the personnel in NIH Clinical Center Biostatistics core.
The major focus will be on the conduction of target trial emulations for identifying treatments for serious infections carrying a high burden of mortality. Signals from such studies could yield critical evidence which could prove life saving for many.
In the planned projects, CES investigators will conduct a retrospective cohort study using clinical and administrative data from the Premier Healthcare Database ©. It is anticipated that this project will involve a primary analysis of data from approximately 500,000 – 1, 000,000 patients. This will be coupled with weighted extrapolations and geospatial analyses using multiple national-level datasets accessible to the investigators to derive a national or quasi-national burdens as well as retrospective chart review from collaborating health centers across the United States to validate some assumptions in the initial cohort study.
Given the expansive nature of the study, there is a need for additional qualified personnel with expertise in statistical analysis to assist in the completion of this work.
Scope of Work:
A Biostatistician team of 2 individuals (senior PHD biostatistician with several years’ experience in academic and cutting edge biostatistical work and one junior Master-level biostatistician) will interface with other members of the Clinical Epidemiology Section, and informatics company (contracted for data curation), to conduct the analysis of data pertaining to several ongoing research studies. The major focus will be on the conduction of target trial emulations for identifying treatments for serious infections carrying a high burden of mortality.
The Biostatisticians will meet with the study investigators on a weekly basis to discuss and plan the data curation steps as well as the cohort design. The actual curation of the data will be performed by the contracted informatics company, but the biostatistician team will be involved from the inception phase in real-time discussions with the data curators to ensure the study dataset is constructed in a manner to enable planned analyses.
The Biostatisticians will receive the curated dataset consisting of clinical and administrative information for patients admitted to hospitals reporting to PHD. They will be responsible for the selection of the matching, weighting and modeling strategies employed to minimize bias including the handling of missing data. They will be responsible the generation of a statistical analysis plan for the proposal (which will be posted online prior to analysis), providing descriptive and summary statistics for the cohorts and identified subgroups, providing periodic presentations of preliminary data and 6-monthly interim analysis reports, as well as for the inferential analysis comparing the outcomes and costs of patients. Preliminary flow diagrams of the retrospective cohorts isolated from the PHD for this study are attached.
Qualifications:
The Senior Biostatisticians must meet the following requirements:
- Have a PhD in Biostatistics
- Have over 10 years of experience in the academic biostatistics, analysis of data from large healthcare datasets
- Have independently led analytics for large-scale, high-impact studies
- Demonstrated ability to independently acquire grant funding
- Have a Master in Biostatistics
Requirements and Period of Performance:
This requirement will include a base year of twelve (12) months, with up to one (1) option period to extend the services solely by the discretion of the government.
Base Year: April 1, 2025, to March 31, 2026
Location:
Work is remote and research will be performed at the George Washington University, Washington, DC 20052
Point of Contact for Immediate Consideration:
Art Mata
amata@reef-syss.com